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What is the most important thing I should know about APRETUDE? Before receiving APRETUDE to reduce your risk of getting HIV-1, you must be HIV-1 negative to start APRETUDE. Do not receive APRETUDE unless you are tested and confirmed to be HIV-1 negative. Some HIV-1 tests can miss HIV-1 infection in a person who has recently become infected. Tell your healthcare provider if you had a flu-like illness within the last month before starting or at any time while receiving APRETUDE. Symptoms of new HIV-1 infection include: tiredness; joint or muscle aches; sore throat; rash; enlarged lymph nodes in the neck or groin; fever; headache; vomiting or diarrhea; or night sweats

Important Safety Information

IMPORTANT SAFETY INFORMATION What is the most important thing I should know about APRETUDE? Important information for people who receive APRETUDE for pre-exposure prophylaxis (PrEP) to help reduce their risk of getting human immunodeficiency virus-1 (HIV-1) infection: Before receiving APRETUDE to reduce your risk of getting HIV-1, you must be HIV-1 negative to start APRETUDE. Do not receive APRETUDE unless you are tested and confirmed to be HIV-1 negative. <ul> <li>Some HIV-1 tests can miss HIV-1 infection in a person who has recently become infected. Tell your healthcare provider if you had a flu-like illness within the last month before starting or at any time while receiving APRETUDE. Symptoms of new HIV-1 infection include: tiredness; joint or muscle aches; sore throat; rash; enlarged lymph nodes in the neck or groin; fever; headache; vomiting or diarrhea; or night sweats </li> </ul> While you are receiving APRETUDE for HIV-1 PrEP: <ul> <li>APRETUDE does not prevent other sexually transmitted infections (STIs). Practice safer sex by using a latex or polyurethane condom to reduce the risk of getting STIs</li> <li>You must stay HIV-1 negative to keep receiving APRETUDE for HIV-1 PrEP</li> <ul style="list-style-type: disc;"> <li>Know your HIV-1 status and the HIV-1 status of your partners. If you think you were exposed to HIV-1, tell your healthcare provider right away</li> <li>Your risk of getting HIV-1 is lower if your partners with HIV-1 are taking effective treatment</li> <li>Get tested for HIV-1 with each APRETUDE injection or when your healthcare provider tells you. You should not miss any HIV-1 tests. If you become HIV-1 infected and continue receiving APRETUDE because you do not know you are HIV-1 infected, the HIV-1 infection may become harder to treat</li> <li>Get tested for other STIs. These infections make it easier for HIV-1 to infect you</li> <li>Talk to your healthcare provider about ways to reduce your HIV-1 risk</li> <li>Do not miss any injections of APRETUDE. Missing injections increases your risk of getting HIV-1 infection</li> </ul> </ul> Who should not receive APRETUDE? Do not receive APRETUDE if you: <ul> <li>already have HIV-1 or do not know your HIV-1 status. If you are HIV-1 positive, you need to take other medicines to treat HIV-1. APRETUDE can only help reduce your risk of getting HIV-1 infection before you are infected. If you have HIV-1 and receive only APRETUDE, over time, your HIV-1 may become harder to treat </li> <li>are allergic to cabotegravir</li> <li>are taking certain medicines: carbamazepine; oxcarbazepine; phenobarbital; phenytoin; rifampin; or rifapentine</li> </ul> What are the possible side effects of APRETUDE? APRETUDE may cause serious side effects: <ul> <li>Allergic reactions. Call your healthcare provider right away if you develop a rash with APRETUDE. Stop receiving APRETUDE and get medical help right away if you develop a rash with any of the following signs or symptoms: fever; generally ill feeling; tiredness; muscle or joint aches; trouble breathing; blisters or sores in mouth; blisters; redness or swelling of the eyes; swelling of the mouth, face, lips, or tongue </li> <li>Liver problems. Liver problems have happened in people with or without a history of liver problems or other risk factors. Call your healthcare provider right away if you have any of the following symptoms: your skin or the white part of your eyes turns yellow; dark or “tea-colored” urine; light-colored stools; nausea or vomiting; loss of appetite; pain, aching, or tenderness on the right side of your stomach area; or itching </li> <li>Depression or mood changes. Call your healthcare provider or get emergency medical help right away if you develop any of the following symptoms: feeling sad or hopeless; feeling anxious or restless; have thoughts of hurting yourself (suicide) or have tried to hurt yourself </li> </ul> The most common side effects of APRETUDE include: <ul> <li>Pain, tenderness, hardened mass or lump, swelling, bruising, redness, itching, warmth, loss of sensation at the injection site, abscess, and discoloration; diarrhea; headache; fever; tiredness; sleep problems; nausea; dizziness; passing gas; stomach pain; vomiting; muscle pain; rash; loss of appetite; drowsiness; back pain; or upper respiratory infection </li> <li>These are not all the possible side effects of APRETUDE. Call your healthcare provider for medical advice about side effects</li> </ul> Before receiving APRETUDE, tell your healthcare provider about all your medical conditions, including if you: <ul> <li>have ever had a skin rash or an allergic reaction to medicines that contain cabotegravir</li> <li>have or have had liver problems</li> <li>have ever had mental health problems</li> <li>are pregnant or plan to become pregnant. It is not known if APRETUDE will harm your unborn baby. APRETUDE can remain in your body for up to 12 months or longer after the last injection. Tell your healthcare provider if you become pregnant while or after receiving APRETUDE </li> <li>are breastfeeding or plan to breastfeed. APRETUDE may pass into your breast milk. Talk with your healthcare provider about the best way to feed your baby while or after receiving APRETUDE</li> </ul> Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. <ul> <li>Some medicines may interact with APRETUDE. Keep a list of your medicines and show it to your healthcare provider and pharmacist. Do not start a new medicine without telling your healthcare provider </li> </ul> How will I receive APRETUDE? <ul> <li>APRETUDE will be given to you as an injection by your healthcare provider</li> <li>APRETUDE is initially given as an injection into the muscle of your buttock 1 time every month for the first 2 months, then as an injection 1 time every 2 months</li> <li>Before receiving your first APRETUDE injection, your healthcare provider may have you take 1 oral cabotegravir tablet 1 time a day for 1 month (at least 28 days) to assess how well you tolerate cabotegravir</li> <li>APRETUDE is a long-acting medicine and may stay in your body for 12 months or longer after your last injection</li> <li>Stay under the care of a healthcare provider while receiving APRETUDE. It is important that you receive APRETUDE as scheduled</li> <li>If you miss or plan to miss a scheduled injection of APRETUDE by more than 7 days, call your healthcare provider right away to discuss your PrEP options</li> <li>If you stop receiving APRETUDE, talk to your healthcare provider about other options to reduce the risk of getting HIV-1 infection</li> </ul> You are encouraged to report negative side effects of prescription drugs to the FDA. Visit <a href="https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program" target="_blank">www.fda.gov/medwatch</a>, or call <a href="tel:1800FDA1088">1-800-FDA-1088</a>. Please read the <a href="https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Apretude/pdf/APRETUDE-PI-PIL-IFU.PDF#page=36" target="_blank">Patient Information</a> for APRETUDE, including an Important Warning, and discuss it with your healthcare provider. PMUS-CBTWCNT240076

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APRETUDE is a prescription medicine used for HIV-1 PrEP to reduce the risk of getting HIV-1 infection in adults and adolescents who weigh at least 77 pounds (at least 35 kg). APRETUDE is the first long-acting injectable PrEP for reducing the risk of getting HIV. That means no more daily PrEP pills to remember or keep track of while you’re receiving your APRETUDE injection every other month. APRETUDE is given every other month by a healthcare provider after initiation injections have been given 1 month apart for 2 consecutive months. Stay under a provider’s care while receiving APRETUDE. You must receive it as scheduled. If you will miss a scheduled injection by more than 7 days, call your provider right away. Get started to connect with a provider and see if APRETUDE may be right for you.

There are daily PrEP pills, and then there's APRETUDE (cabotegravir).

There is a $25 fee for the telehealth visit. If your prescription is approved, the cost of your medication will be determined by your personal health insurance. There may be additional lab testing and product administration fees. Access to APRETUDE via telehealth may be restricted to specific locations. By clicking the link below, you will be directed to an UpScript portal that is neither owned nor controlled by ViiV Healthcare. ViiV Healthcare is not responsible for the content or services of this third-party portal. The healthcare professionals that are available via UpScript are independent and will exercise autonomous clinical judgement in evaluating any medical conditions and resulting care decisions, which may or may not include medication. <a href="https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Apretude/pdf/APRETUDE-PI-PIL-IFU.PDF" target="_blank" style="font-size: 13px;">Click here to See full prescribing info, Patient Info & Boxed Warning. ></a>

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Select a telehealth visit and register with UpScript. <a href="https://www.apretudeonline.com/how-it-works/entry?pid=1515" style="color: #6c3175; font-weight: bold;">Get Started &gt;</a>

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To get started with the telehealth process, complete a medical questionnaire to help your healthcare providers better understand your medical history.

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Attend a private online consultation with a medical expert to determine whether APRETUDE is right for you. You can schedule a telehealth appointment that's convenient for you. There is a $25 fee for the telehealth visit. If your prescription is approved, the cost of your medication will be determined by your personal health insurance. There may be additional lab testing and product administration fees. Your healthcare providers will determine which medicine, if any, is right for you and there is no guarantee of prescription.

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An UpScript care coordinator will send you an email and confirm next steps. PMUS-CBTWCNT240077

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UpScript can help you begin your APRETUDE journey, including assistance with benefits verification—all via telehealth.  

APRETUDE (cabotegravir) is available via UpScript.

Find out how ApretudeOnline connects you with a provider. Learn about APRETUDE (cabotegravir).

Gone are the days of in-person doctor visits, exposure to sick patients, and long lines at the pharmacy. UpScript has all the treatments you need with on-call medical experts here to get you feeling fantastic, faster than ever.

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How ApretudeOnline Works | See Boxed Warning | APRETUDE (cabotegravir)

Register, access your account details, schedule and pay for your online visit all in one place. The system will guide you through the registration, medical questionnaire, appointment scheduling and payment process. Already registered? Please click the "Already have an account?" link on this page to log in. All content is owned by UpScript and is neither influenced nor overseen by ViiV Healthcare.

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